In vitro Effect of Pomegranate Peel Extract on Trichomonas tenax
نویسندگان
چکیده
The incidence of Trichomonas tenax (T. tenax) in patients with acute ulcerative gingivitis has been demonstrated in several published reports. Metronidazole was known as the most effective drug for human trichomoniasis, however, drug resistance and toxicity appeared. This study was designed in vitro to investigate the inhibitory activity of Punica granatum (P. granatun) ethanol extract on the growth and motility of T. tenax in comparison to metronidazole. Pomegranate ethanol extract group was treated with concentrations of 12.5, 25, 50, and 100 μg/ml. Metronidazole group and blank control were included. At 12 h, 24 h 48 h and 72 hr after drug treatment, the anti-T. tenax effect of pomegranate ethanol extract was tested by microscope counting method. The results showed 60% motility of T.tenax trophozoite after treatment with 12.5μg/100 ml of pomegranate ethanol extract group and 25 μg/ml showed higher anti-T. tenax (P<0.01). The ethanol extract of pomegranate peel has a remarkable effect on T. tenax, and among the groups, 60% ethanol extract shows the best anti-T. tenax activity. [Gehad T. El-Sherbini and Nahla M. Shoukry In Vitro effect of pomegranate peel extract on Trichomonas tenax] Life Science Journal 2012; 9(3):791-797]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 113
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